diff --git a/src/backends/cl/workloads/ClChannelShuffleWorkload.cpp b/src/backends/cl/workloads/ClChannelShuffleWorkload.cpp
index 9ce0571..0e10b37 100644
--- a/src/backends/cl/workloads/ClChannelShuffleWorkload.cpp
+++ b/src/backends/cl/workloads/ClChannelShuffleWorkload.cpp
@@ -1,5 +1,5 @@
 //
-// Copyright © 2021-2023 Arm Ltd and Contributors. All rights reserved.
+// Copyright © 2021-2024 Arm Ltd and Contributors. All rights reserved.
 // SPDX-License-Identifier: MIT
 //
 
@@ -80,8 +80,8 @@
             aclDataLayout = ConvertDataLayout(armnn::DataLayout::NHWC);
             break;
         default:
-            ARMNN_ASSERT_MSG(false, "Unsupported axis");
-            break;
+            throw InvalidArgumentException("Value for axis: " + std::to_string(descriptor.m_Parameters.m_Axis) +
+                                           " is not valid");
     }
     input.info()->set_data_layout(aclDataLayout);
     output.info()->set_data_layout(aclDataLayout);
diff --git a/src/backends/cl/workloads/ClConstantWorkload.cpp b/src/backends/cl/workloads/ClConstantWorkload.cpp
index bbf6476..619c0f8 100644
--- a/src/backends/cl/workloads/ClConstantWorkload.cpp
+++ b/src/backends/cl/workloads/ClConstantWorkload.cpp
@@ -1,5 +1,5 @@
 //
-// Copyright © 2017-2018,2020-2023 Arm Ltd and Contributors. All rights reserved.
+// Copyright © 2017-2018,2020-2024 Arm Ltd and Contributors. All rights reserved.
 // SPDX-License-Identifier: MIT
 //
 
@@ -61,7 +61,7 @@
     {
         const ConstantQueueDescriptor& data = this->m_Data;
 
-        ARMNN_ASSERT(data.m_LayerOutput != nullptr);
+        ARMNN_THROW_INVALIDARG_MSG_IF_FALSE(data.m_LayerOutput, "Output tensor handle is null.");
         arm_compute::CLTensor& output = static_cast<ClTensorHandle*>(data.m_Outputs[0])->GetTensor();
         arm_compute::DataType computeDataType = static_cast<ClTensorHandle*>(data.m_Outputs[0])->GetDataType();
 
@@ -105,8 +105,7 @@
             }
             default:
             {
-                ARMNN_ASSERT_MSG(false, "Unknown data type");
-                break;
+                throw InvalidArgumentException("Unknown data type.");
             }
         }
 
diff --git a/src/backends/cl/workloads/ClConvolution2dWorkload.cpp b/src/backends/cl/workloads/ClConvolution2dWorkload.cpp
index 2fc174c..7ae09e3 100644
--- a/src/backends/cl/workloads/ClConvolution2dWorkload.cpp
+++ b/src/backends/cl/workloads/ClConvolution2dWorkload.cpp
@@ -1,5 +1,5 @@
 //
-// Copyright © 2017-2023 Arm Ltd and Contributors. All rights reserved.
+// Copyright © 2017-2024 Arm Ltd and Contributors. All rights reserved.
 // SPDX-License-Identifier: MIT
 //
 
@@ -99,7 +99,8 @@
         arm_compute::ICLTensor& bias = static_cast<IClTensorHandle*>(m_Data.m_Inputs[2])->GetTensor();
         bias.info()->set_are_values_constant(info.m_InputTensorInfos[2].IsConstant());
         // We assume here that NeonConvolution2dWorkloadValidate has been called before the constructor.
-        ARMNN_ASSERT(info.m_InputTensorInfos[2].IsConstant() == true);
+        ARMNN_THROW_INVALIDARG_MSG_IF_FALSE(info.m_InputTensorInfos[2].IsConstant() == true,
+                                            "The bias tensor must be constant.");
         m_BiasProxy = std::make_unique<ICLTensorProxy>(&bias);
     }
 
diff --git a/src/backends/cl/workloads/ClDepthwiseConvolutionWorkload.cpp b/src/backends/cl/workloads/ClDepthwiseConvolutionWorkload.cpp
index e5ee9b9..088814b 100644
--- a/src/backends/cl/workloads/ClDepthwiseConvolutionWorkload.cpp
+++ b/src/backends/cl/workloads/ClDepthwiseConvolutionWorkload.cpp
@@ -1,5 +1,5 @@
 //
-// Copyright © 2017-2023 Arm Ltd and Contributors. All rights reserved.
+// Copyright © 2017-2024 Arm Ltd and Contributors. All rights reserved.
 // SPDX-License-Identifier: MIT
 //
 
@@ -140,7 +140,6 @@
                 activationInfo,
                 aclDilationInfo);
     }
-    ARMNN_ASSERT(m_DepthwiseConvolutionLayer);
 
     // Add details for profiling output
     WorkloadInfo detailsInfo;
@@ -158,7 +157,6 @@
 void ClDepthwiseConvolutionWorkload::Execute() const
 {
     ARMNN_SCOPED_PROFILING_EVENT_CL_NAME_GUID("ClDepthwiseConvolutionWorkload_Execute");
-    ARMNN_ASSERT(m_DepthwiseConvolutionLayer);
 
     RunClFunction(*m_DepthwiseConvolutionLayer, CHECK_LOCATION());
 }
diff --git a/src/backends/cl/workloads/ClFullyConnectedWorkload.cpp b/src/backends/cl/workloads/ClFullyConnectedWorkload.cpp
index 959f430..0b6606f 100644
--- a/src/backends/cl/workloads/ClFullyConnectedWorkload.cpp
+++ b/src/backends/cl/workloads/ClFullyConnectedWorkload.cpp
@@ -1,5 +1,5 @@
 //
-// Copyright © 2017-2018,2020-2023 Arm Ltd and Contributors. All rights reserved.
+// Copyright © 2017-2018,2020-2024 Arm Ltd and Contributors. All rights reserved.
 // SPDX-License-Identifier: MIT
 //
 
@@ -32,7 +32,9 @@
     arm_compute::TensorInfo* optionalAclBiases = nullptr;
     if (descriptor.m_BiasEnabled)
     {
-        ARMNN_ASSERT(biases.has_value());
+        ARMNN_THROW_INVALIDARG_MSG_IF_FALSE(
+            biases.has_value(),
+            "ClFullyConnectedWorkload: Bias was enabled in the descriptor but no value was supplied.");
         aclBiases = BuildArmComputeTensorInfo(biases.value());
         aclBiases.set_are_values_constant(biases.value().IsConstant());
         optionalAclBiases = &aclBiases;
diff --git a/src/backends/cl/workloads/ClGatherNdWorkload.cpp b/src/backends/cl/workloads/ClGatherNdWorkload.cpp
index 1351f96..4e9dd75 100644
--- a/src/backends/cl/workloads/ClGatherNdWorkload.cpp
+++ b/src/backends/cl/workloads/ClGatherNdWorkload.cpp
@@ -1,5 +1,5 @@
 //
-// Copyright © 2022-2023 Arm Ltd and Contributors. All rights reserved.
+// Copyright © 2022-2024 Arm Ltd and Contributors. All rights reserved.
 // SPDX-License-Identifier: MIT
 //
 
@@ -142,8 +142,6 @@
     flattenedCoeff_Info.SetShape({ keyIndices["ND"] });
     BuildArmComputeTensor(m_FlattenedCoeff, flattenedCoeff_Info);
     armcomputetensorutils::InitialiseArmComputeTensorEmpty(m_FlattenedCoeff);
-    ARMNN_ASSERT_MSG(indicesInfo.GetDataType() == DataType::Signed32,
-                     "flattenedCoeff must be same data type as m_FlattenedCoeff");
     CopyArmComputeClTensorData<int32_t>(m_FlattenedCoeff, flattenedCoeff.data());
 
     // Prepare the tensor to store the output of the multiplication
diff --git a/src/backends/cl/workloads/ClSqrtWorkload.cpp b/src/backends/cl/workloads/ClSqrtWorkload.cpp
index e36adf6..d41584e 100644
--- a/src/backends/cl/workloads/ClSqrtWorkload.cpp
+++ b/src/backends/cl/workloads/ClSqrtWorkload.cpp
@@ -1,5 +1,5 @@
 //
-// Copyright © 2022-2023 Arm Ltd and Contributors. All rights reserved.
+// Copyright © 2022-2024 Arm Ltd and Contributors. All rights reserved.
 // SPDX-License-Identifier: MIT
 //
 
@@ -34,7 +34,10 @@
                                const arm_compute::CLCompileContext& clCompileContext)
     : ClBaseWorkload<ElementwiseUnaryQueueDescriptor>(descriptor, info)
 {
-    ARMNN_ASSERT(descriptor.m_Parameters.m_Operation == UnaryOperation::Sqrt);
+    if (descriptor.m_Parameters.m_Operation != UnaryOperation::Sqrt)
+    {
+        throw InvalidArgumentException("ClSqrtWorkload: The descriptor does not indicate a Sqrt operation.");
+    }
 
     // Report Profiling Details
     ARMNN_REPORT_PROFILING_WORKLOAD_DESC("ClSqrtWorkload_Construct",
diff --git a/src/backends/cl/workloads/ClTransposeConvolution2dWorkload.cpp b/src/backends/cl/workloads/ClTransposeConvolution2dWorkload.cpp
index d3eeade..c3fafd4 100644
--- a/src/backends/cl/workloads/ClTransposeConvolution2dWorkload.cpp
+++ b/src/backends/cl/workloads/ClTransposeConvolution2dWorkload.cpp
@@ -1,5 +1,5 @@
 //
-// Copyright © 2019-2023 Arm Ltd and Contributors. All rights reserved.
+// Copyright © 2019-2024 Arm Ltd and Contributors. All rights reserved.
 // SPDX-License-Identifier: MIT
 //
 
@@ -38,8 +38,11 @@
 
     if (descriptor.m_BiasEnabled)
     {
-        ARMNN_ASSERT(biases.has_value());
-
+        if (!biases.has_value())
+        {
+            return arm_compute::Status{arm_compute::ErrorCode::RUNTIME_ERROR,
+                                        "ArmNN ClTransposeConv2dWorkload has empty bias value."};
+        }
         aclBiasesInfo = BuildArmComputeTensorInfo(biases.value(), descriptor.m_DataLayout);
         optionalAclBiasesInfo = &aclBiasesInfo;
     }
diff --git a/src/backends/cl/workloads/ClWorkloadUtils.hpp b/src/backends/cl/workloads/ClWorkloadUtils.hpp
index 4b491e3..78b09b0 100644
--- a/src/backends/cl/workloads/ClWorkloadUtils.hpp
+++ b/src/backends/cl/workloads/ClWorkloadUtils.hpp
@@ -1,5 +1,5 @@
 //
-// Copyright © 2017-2023 Arm Ltd and Contributors. All rights reserved.
+// Copyright © 2017-2024 Arm Ltd and Contributors. All rights reserved.
 // SPDX-License-Identifier: MIT
 //
 #pragma once
@@ -124,8 +124,7 @@
 inline void InitializeArmComputeClTensorData(arm_compute::CLTensor& clTensor,
                                              const ConstTensorHandle* handle)
 {
-    ARMNN_ASSERT(handle);
-
+    ARMNN_THROW_INVALIDARG_MSG_IF_FALSE(handle, "Null tensor handle passed to InitializeArmComputeTensorData.");
     armcomputetensorutils::InitialiseArmComputeTensorEmpty(clTensor);
     switch(handle->GetTensorInfo().GetDataType())
     {