diff --git a/applications/trustzone_inference/secure/CMakeLists.txt b/applications/trustzone_inference/secure/CMakeLists.txt
new file mode 100644
index 0000000..1e4a98b
--- /dev/null
+++ b/applications/trustzone_inference/secure/CMakeLists.txt
@@ -0,0 +1,69 @@
+#
+# Copyright (c) 2021 Arm Limited. All rights reserved.
+#
+# SPDX-License-Identifier: Apache-2.0
+#
+# Licensed under the Apache License, Version 2.0 (the License); you may
+# not use this file except in compliance with the License.
+# You may obtain a copy of the License at
+#
+# www.apache.org/licenses/LICENSE-2.0
+#
+# Unless required by applicable law or agreed to in writing, software
+# distributed under the License is distributed on an AS IS BASIS, WITHOUT
+# WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+# See the License for the specific language governing permissions and
+# limitations under the License.
+#
+
+include(${CMAKE_CURRENT_SOURCE_DIR}/../../../cmake/helpers.cmake)
+
+#############################################################################
+# Configuration for secure world
+#############################################################################
+
+set(TRUSTZONE_BUILD TRUE)
+set(TRUSTZONE_SIDE secure)
+
+#############################################################################
+# TrustZone secure world
+#############################################################################
+
+ethosu_add_executable(trustzone_secure PRIVATE
+    SOURCES main_secure.cpp mpc_sie_drv.c
+    LIBRARIES ethosu_target_init)
+
+target_compile_definitions(trustzone_secure PUBLIC TRUSTZONE_BUILD)
+target_compile_definitions(trustzone_secure PUBLIC TRUSTZONE_SECURE)
+
+# Use the fast memory to support both 11.12.57 and 11.13.x release
+# of the FVP
+target_compile_definitions(
+    trustzone_secure PUBLIC ETHOSU_FAST_MEMORY_SIZE=0xa0000)
+
+target_compile_options(trustzone_secure PUBLIC -mcmse)
+
+# Add include directory for target application specifics
+target_include_directories(trustzone_secure PUBLIC ${CMAKE_CURRENT_SOURCE_DIR}/../${ETHOSU_TARGET})
+
+#############################################################################
+# Additional linker configuration for trustzone
+#############################################################################
+
+# Output the secure gateway veneer library to be consumed by the build
+# process for the non-secure world
+target_link_options(trustzone_secure
+    PRIVATE --import_cmse_lib_out=${SECURE_GATEWAY_LIB})
+
+target_link_options(trustzone_secure
+    PRIVATE "--predefine=\"-I${CMAKE_CURRENT_SOURCE_DIR}/../${ETHOSU_TARGET}\"")
+
+#############################################################################
+# Helper target to extract secure binaries
+#############################################################################
+
+add_custom_target(secure_binary ALL COMMAND fromelf --bin
+    ${CMAKE_CURRENT_BINARY_DIR}/trustzone_secure.elf
+     -o ${CMAKE_CURRENT_BINARY_DIR}/s_bin
+    DEPENDS ${CMAKE_CURRENT_BINARY_DIR}/trustzone_secure)
+