diff --git a/targets/corstone-300/CMakeLists.txt b/targets/corstone-300/CMakeLists.txt
index 538a978..e791cfd 100644
--- a/targets/corstone-300/CMakeLists.txt
+++ b/targets/corstone-300/CMakeLists.txt
@@ -28,6 +28,8 @@
 
 set(ETHOSU_COMMAND_DEFAULT ${CMAKE_CURRENT_SOURCE_DIR}/../../scripts/run_ctest.py -t corstone-300)
 
+option(CPU_CACHE_ENABLE "Enable CPU instruction- and data cache" ON)
+
 #############################################################################
 # Project
 #############################################################################
@@ -59,6 +61,11 @@
     ETHOSU_NPU_TA_COUNT=${ETHOSU_TARGET_NPU_TA_COUNT}
     ETHOSU_NPU_COUNT=${ETHOSU_TARGET_NPU_COUNT})
 
+if (CPU_CACHE_ENABLE)
+    target_compile_definitions(ethosu_target_common INTERFACE
+        CPU_CACHE_ENABLE)
+endif()
+
 # Linker script
 ethosu_target_link_options(ethosu_target_link INTERFACE
     LINK_FILE platform
@@ -68,7 +75,8 @@
 target_sources(ethosu_target_startup INTERFACE
     retarget.c
     uart.c
-    target.cpp)
+    target.cpp
+    mpu.cpp)
 
 target_compile_definitions(ethosu_core_driver PUBLIC ETHOSU)
 target_link_libraries(ethosu_target_startup INTERFACE ethosu_core_driver timing_adapter)
diff --git a/targets/corstone-300/mpu.cpp b/targets/corstone-300/mpu.cpp
new file mode 100644
index 0000000..645723c
--- /dev/null
+++ b/targets/corstone-300/mpu.cpp
@@ -0,0 +1,79 @@
+/*
+ * Copyright (c) 2020-2021 Arm Limited. All rights reserved.
+ *
+ * SPDX-License-Identifier: Apache-2.0
+ *
+ * Licensed under the Apache License, Version 2.0 (the License); you may
+ * not use this file except in compliance with the License.
+ * You may obtain a copy of the License at
+ *
+ * www.apache.org/licenses/LICENSE-2.0
+ *
+ * Unless required by applicable law or agreed to in writing, software
+ * distributed under the License is distributed on an AS IS BASIS, WITHOUT
+ * WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+ * See the License for the specific language governing permissions and
+ * limitations under the License.
+ */
+
+/****************************************************************************
+ * Includes
+ ****************************************************************************/
+
+#include "mpu.hpp"
+
+#include <cachel1_armv7.h>
+#include <inttypes.h>
+#include <stdio.h>
+
+using namespace std;
+
+/****************************************************************************
+ * Functions
+ ****************************************************************************/
+
+namespace EthosU {
+namespace Mpu {
+
+void dump() {
+#ifdef ARM_MPU_ARMV8_H
+    uint32_t mpuRegions = (MPU->TYPE & MPU_TYPE_DREGION_Msk) >> MPU_TYPE_DREGION_Pos;
+
+    printf("MPU available with " PRIu32 " regions.\n", mpuRegions);
+
+    printf("    PRIVDEFENA : %lx\n", (MPU->CTRL & MPU_CTRL_PRIVDEFENA_Msk) >> MPU_CTRL_PRIVDEFENA_Pos);
+    printf("      HFNMIENA : %lx\n", (MPU->CTRL & MPU_CTRL_HFNMIENA_Msk) >> MPU_CTRL_HFNMIENA_Pos);
+    printf("        ENABLE : %lx\n", (MPU->CTRL & MPU_CTRL_ENABLE_Msk) >> MPU_CTRL_ENABLE_Pos);
+
+    for (size_t region = 0; region < mpuRegions; region++) {
+        MPU->RNR = region;
+        printf("-- Region %2d - RBAR:%08" PRIx32 " RLAR:%08" PRIx32 "\n", region, MPU->RBAR, MPU->RLAR);
+    }
+#endif
+}
+
+static void initializeAttributes() {
+#ifdef ARM_MPU_ARMV8_H
+    /* Initialize attributes corresponding to the enums defined in mpu.hpp */
+    const uint8_t WTRA =
+        ARM_MPU_ATTR_MEMORY_(1, 0, 1, 0); // Non-transient, Write-Through, Read-allocate, Not Write-allocate
+    const uint8_t WBWARA = ARM_MPU_ATTR_MEMORY_(1, 1, 1, 1); // Non-transient, Write-Back, Read-allocate, Write-allocate
+
+    ARM_MPU_SetMemAttr(WTRA_index, ARM_MPU_ATTR(WTRA, WTRA));
+    ARM_MPU_SetMemAttr(WBWARA_index, ARM_MPU_ATTR(WBWARA, WBWARA));
+#endif
+}
+
+void loadAndEnableConfig(ARM_MPU_Region_t const *table, uint32_t cnt) {
+#ifdef ARM_MPU_ARMV8_H
+    initializeAttributes();
+
+    ARM_MPU_Load(0, table, cnt);
+
+    // Enable MPU with default priv access to all other regions
+    ARM_MPU_Enable(MPU_CTRL_PRIVDEFENA_Msk);
+#endif
+}
+
+}; // namespace Mpu
+}; // namespace EthosU
diff --git a/targets/corstone-300/mpu.hpp b/targets/corstone-300/mpu.hpp
new file mode 100644
index 0000000..dff73b6
--- /dev/null
+++ b/targets/corstone-300/mpu.hpp
@@ -0,0 +1,42 @@
+/*
+ * Copyright (c) 2020-2021 Arm Limited. All rights reserved.
+ *
+ * SPDX-License-Identifier: Apache-2.0
+ *
+ * Licensed under the Apache License, Version 2.0 (the License); you may
+ * not use this file except in compliance with the License.
+ * You may obtain a copy of the License at
+ *
+ * www.apache.org/licenses/LICENSE-2.0
+ *
+ * Unless required by applicable law or agreed to in writing, software
+ * distributed under the License is distributed on an AS IS BASIS, WITHOUT
+ * WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
+ * See the License for the specific language governing permissions and
+ * limitations under the License.
+ */
+
+/****************************************************************************
+ * Includes
+ ****************************************************************************/
+
+#include <cstdint>
+
+/****************************************************************************
+ * Types and functions
+ ****************************************************************************/
+
+namespace EthosU {
+namespace Mpu {
+
+enum { WTRA_index, WBWARA_index };
+
+/**
+ * Dump the MPU tables.
+ */
+void dump();
+
+void loadAndEnableConfig(ARM_MPU_Region_t const *table, uint32_t cnt);
+
+}; // namespace Mpu
+}; // namespace EthosU
diff --git a/targets/corstone-300/target.cpp b/targets/corstone-300/target.cpp
index e5f4680..a44c12f 100644
--- a/targets/corstone-300/target.cpp
+++ b/targets/corstone-300/target.cpp
@@ -26,6 +26,7 @@
 #include <ethosu_driver.h>
 #endif
 
+#include "mpu.hpp"
 #include <timing_adapter.h>
 
 #include "uart.h"
@@ -33,6 +34,7 @@
 #include <inttypes.h>
 #include <stdio.h>
 #include <stdlib.h>
+#include <vector>
 
 using namespace EthosU;
 
@@ -57,6 +59,10 @@
 #define ETHOSU_FAST_MEMORY_SIZE 0
 #endif
 
+#ifdef ETHOSU
+struct ethosu_driver *ethosu0_driver = &ethosu_drv;
+#endif
+
 static uintptr_t ethosu_ta_base_addrs[ETHOSU_NPU_COUNT][ETHOSU_NPU_TA_COUNT] = {
     {ETHOSU0_TA0_BASE_ADDRESS, ETHOSU0_TA1_BASE_ADDRESS}};
 struct timing_adapter ethosu_ta[ETHOSU_NPU_COUNT][ETHOSU_NPU_TA_COUNT];
@@ -152,15 +158,90 @@
 
 #ifdef ETHOSU
     // Initialize Ethos-U NPU driver
-    if (ethosu_init_v3(reinterpret_cast<void *>(ETHOSU_BASE_ADDRESS), ethosu_scratch, ETHOSU_FAST_MEMORY_SIZE, 1, 1)) {
+    if (ethosu_init_v4(ethosu0_driver,
+                       reinterpret_cast<void *>(ETHOSU_BASE_ADDRESS),
+                       ethosu_scratch,
+                       ETHOSU_FAST_MEMORY_SIZE,
+                       1,
+                       1)) {
         printf("Failed to initialize NPU.\n");
         return;
     }
 
-    /* Assumes SCB->VTOR point to RW memory */
+    // Assumes SCB->VTOR point to RW memory
     NVIC_SetVector(static_cast<IRQn_Type>(ETHOSU_IRQ), (uint32_t)&ethosuIrqHandler);
     NVIC_EnableIRQ(static_cast<IRQn_Type>(ETHOSU_IRQ));
 #endif
+
+    // MPU setup
+    const std::vector<ARM_MPU_Region_t> mpuConfig = {
+        {
+            // ITCM
+            ARM_MPU_RBAR(0x00000000,      // Base
+                         ARM_MPU_SH_NON,  // Non-shareable
+                         1,               // Read-Only
+                         1,               // Non-Privileged
+                         0),              // eXecute Never disabled
+            ARM_MPU_RLAR(0x0007ffff,      // Limit
+                         Mpu::WTRA_index) // Attribute index - Write-Through, Read-allocate
+        },
+        {
+            // ITCM
+            ARM_MPU_RBAR(0x10000000,      // Base
+                         ARM_MPU_SH_NON,  // Non-shareable
+                         1,               // Read-Only
+                         1,               // Non-Privileged
+                         0),              // eXecute Never disabled
+            ARM_MPU_RLAR(0x1007ffff,      // Limit
+                         Mpu::WTRA_index) // Attribute index - Write-Through, Read-allocate
+        },
+        {
+            // FPGA DATA SRAM; BRAM
+            ARM_MPU_RBAR(0x11000000,        // Base
+                         ARM_MPU_SH_NON,    // Non-shareable
+                         0,                 // Read-Write
+                         1,                 // Non-Privileged
+                         0),                // eXecute Never disabled
+            ARM_MPU_RLAR(0x111fffff,        // Limit
+                         Mpu::WBWARA_index) // Attribute index - Write-Back, Write-Allocate, Read-allocate
+        },
+        {
+            // DTCM
+            ARM_MPU_RBAR(0x30000000,        // Base
+                         ARM_MPU_SH_NON,    // Non-shareable
+                         0,                 // Read-Write
+                         1,                 // Non-Privileged
+                         1),                // eXecute Never enabled
+            ARM_MPU_RLAR(0x3007ffff,        // Limit
+                         Mpu::WBWARA_index) // Attribute index - Write-Back, Write-Allocate, Read-allocate
+        },
+        {
+            // SSE-300 internal SRAM
+            ARM_MPU_RBAR(0x31000000,        // Base
+                         ARM_MPU_SH_NON,    // Non-shareable
+                         0,                 // Read-Write
+                         1,                 // Non-Privileged
+                         1),                // eXecute Never enabled
+            ARM_MPU_RLAR(0x313fffff,        // Limit
+                         Mpu::WBWARA_index) // Attribute index - Write-Back, Write-Allocate, Read-allocate
+        },
+        {
+            ARM_MPU_RBAR(0x70000000,        // Base
+                         ARM_MPU_SH_NON,    // Non-shareable
+                         0,                 // Read-Write
+                         1,                 // Non-Privileged
+                         1),                // eXecute Never enabled
+            ARM_MPU_RLAR(0x7fffffff,        // Limit
+                         Mpu::WBWARA_index) // Attribute index - Write-Back, Write-Allocate, Read-allocate
+        }};
+
+    // Setup MPU configuration
+    Mpu::loadAndEnableConfig(&mpuConfig[0], mpuConfig.size());
+
+#if defined(CPU_CACHE_ENABLE) && defined(__DCACHE_PRESENT) && (__DCACHE_PRESENT == 1U)
+    SCB_EnableICache();
+    SCB_EnableDCache();
+#endif
 }
 
 } // namespace EthosU